RNA-seq analysis of the brain of mice following recombinant HSV-1 carrying the S302A mutation in vUNG and the repaired HSV-1 strain
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 4 × B6 Wt infected with vUNG-S302A vs 4 × B6 Wt infected with vUNG-repai vs 4 × A1 delta infected with vUNG-repai vs 2 × A1 delta infected with vUNG-S302AGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Herpes simplex virus 1 evades APOBEC1-mediated immunity via its uracil-DNA glycosylase in miceNature microbiology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276253_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1156166 and SRA study SRP530274. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 4 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8494143 B6 Wt infected with vUNG-S302A_1 B6 Wt infected with vUN…
- GSM8494144 B6 Wt infected with vUNG-S302A_2 B6 Wt infected with vUN…
- GSM8494145 B6 Wt infected with vUNG-S302A_3 B6 Wt infected with vUN…
- GSM8494146 B6 Wt infected with vUNG-S302A_4 B6 Wt infected with vUN…
- GSM8494147 B6 Wt infected with vUNG-repair_1 B6 Wt infected with vUN…
- GSM8494148 B6 Wt infected with vUNG-repair_2 B6 Wt infected with vUN…
- GSM8494149 B6 Wt infected with vUNG-repair_3 B6 Wt infected with vUN…
- GSM8494150 B6 Wt infected with vUNG-repair_4 B6 Wt infected with vUN…
- GSM8494151 A1 delta infected with vUNG-S302A_1 A1 delta infected with …
- GSM8494152 A1 delta infected with vUNG-S302A_2 A1 delta infected with …
- GSM8494153 A1 delta infected with vUNG-repair_1 A1 delta infected with …
- GSM8494154 A1 delta infected with vUNG-repair_2 A1 delta infected with …
- GSM8494155 A1 delta infected with vUNG-repair_3 A1 delta infected with …
- GSM8494156 A1 delta infected with vUNG-repair_4 A1 delta infected with …
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.