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Butylphthalide may inhibit blood-brain barrier disruption through complement-related pathways to alleviate cognitive impairment in epileptic mice

GSE277743 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/09/21 Platform GPL23479
Summary
To investigate the effect of butylphthalein (NBP) on gene expression after epileptic seizures, we used RNA sequencing (RNA seq) to analyze the mRNA expression after NBP treatment. The volcano plots between Sham, KA, and KA+NBP groups clearly show different gene distributions. Finally, we found that 754 shared genes overlapped between these differentially expressed genes, which was reversed by NBP treatment.
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Direct links to NCBI, no account and no request form: the whole study as GSE277743_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1163718 and SRA study SRP534018. Searching any of these in the dataset finder brings you back here.

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