Adar1 as a placental innate immune rheostat to prevent endogenous dsRNA-induced integrated stress response-dependent embryonic lethality
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 5 × Adar1 ko placenta seq vs 5 × Adar1 wt placenta seqGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279053_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1159182 and SRA study SRP533895. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8560188 snRNA-Seq of mus musculus: Adar1 ko placenta seq1 Adar1 ko placenta seq
- GSM8560189 snRNA-Seq of mus musculus: Adar1 ko placenta seq2 Adar1 ko placenta seq
- GSM8560190 snRNA-Seq of mus musculus: Adar1 ko placenta seq3 Adar1 ko placenta seq
- GSM8560191 snRNA-Seq of mus musculus: Adar1 ko placenta seq4 Adar1 ko placenta seq
- GSM8560192 snRNA-Seq of mus musculus: Adar1 ko placenta seq5 Adar1 ko placenta seq
- GSM8560193 snRNA-Seq of mus musculus: Adar1 wt placenta seq1 Adar1 wt placenta seq
- GSM8560194 snRNA-Seq of mus musculus: Adar1 wt placenta seq2 Adar1 wt placenta seq
- GSM8560195 snRNA-Seq of mus musculus: Adar1 wt placenta seq3 Adar1 wt placenta seq
- GSM8560196 snRNA-Seq of mus musculus: Adar1 wt placenta seq4 Adar1 wt placenta seq
- GSM8560197 snRNA-Seq of mus musculus: Adar1 wt placenta seq5 Adar1 wt placenta seq
- GSE279579 Adar1 as a placental innate immune rheostat to prevent endogenous dsRNA-induced integrated stress response-dependent embryonic lethality [bulk RNA-seq] 14 samples shares adar1, response-dependent, dsrna-induced, endogenous, integrated, placental, embryonic, lethality
- GSE279582 Adar1 as a placental innate immune rheostat to prevent endogenous dsRNA-induced integrated stress response-dependent embryonic lethality [Adar1 PKO RNA-seq] 14 samples shares adar1, response-dependent, dsrna-induced, endogenous, integrated, placental, embryonic, lethality
- GSE124216 Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues 103 samples shares endogenous, embryonic
- GSE293177 A genome-wide screen reveals Ints7 deficiency activates endogenous retrovirus MERVL, accompanied by anastasis of embryonic stem cells [E14TG2a] 16 samples shares endogenous, embryonic
- GSE300876 A genome-wide screen reveals Ints7 deficiency activates endogenous retrovirus MERVL, accompanied by anastasis of embryonic stem cells [CUT&Tag] 12 samples shares endogenous, embryonic
- GSE234570 GGNBP2 regulates MDA5 sensing triggered by self double stranded RNA following loss of ADAR1 editing 95 samples shares adar1
- GSE233452 Fractionation of sgControl, sgIfih1 and sgGgnbp2 in HoxA9 immortalized Rosa26-CreERT2 Adar1fl/E861A immortalised myeloid cells. 54 samples shares adar1
- GSE87068 RNA Sequencing Quantitative Analysis of RNA editing sites of Wild Type and ADAR1 editing deficient (ADAR1E861A) murine fetal RNA of various tissues 43 samples shares adar1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.