Adar1 as a placental innate immune rheostat to prevent endogenous dsRNA-induced integrated stress response-dependent embryonic lethality [Adar1 PKO RNA-seq]
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279582_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1169857 and SRA study SRP538209. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 14 more — browse all 14 samples with per-sample file links →
- GSE279579 Adar1 as a placental innate immune rheostat to prevent endogenous dsRNA-induced integrated stress response-dependent embryonic lethality [bulk RNA-seq] 14 samples shares adar1, response-dependent, dsrna-induced, endogenous, integrated, placental, embryonic
- GSE279053 Adar1 as a placental innate immune rheostat to prevent endogenous dsRNA-induced integrated stress response-dependent embryonic lethality 10 samples shares adar1, response-dependent, dsrna-induced, endogenous, integrated, placental, embryonic
- GSE234570 GGNBP2 regulates MDA5 sensing triggered by self double stranded RNA following loss of ADAR1 editing 95 samples shares adar1
- GSE233452 Fractionation of sgControl, sgIfih1 and sgGgnbp2 in HoxA9 immortalized Rosa26-CreERT2 Adar1fl/E861A immortalised myeloid cells. 54 samples shares adar1
- GSE87068 RNA Sequencing Quantitative Analysis of RNA editing sites of Wild Type and ADAR1 editing deficient (ADAR1E861A) murine fetal RNA of various tissues 43 samples shares adar1
- GSE255661 Effect of conditional SMC specific deletion of ADAR1 on mouse aortic single cell transcriptomic profile and effect on atherosclerosis 22 samples shares adar1
- GSE233590 Tamoxifen timecourse in HoxA9 immortalized R26-CreERT2 Adar1fl/+ and R26-CreERT2 Adar1fl/E861A myeliod cell lines. 16 samples shares adar1
- GSE289275 Loss of ADAR1 in tumor cells activates cDC1s and sensitizes pancreatic cancer to immunotherapy 14 samples shares adar1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.