Adar1 as a placental innate immune rheostat to prevent endogenous dsRNA-induced integrated stress response-dependent embryonic lethality [bulk RNA-seq]
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 14 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279579_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1172339 and SRA study SRP538302. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 14 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8576343 RNA-Seq of mus musculus:E100075418_L01_9171_1
- GSM8576344 RNA-Seq of mus musculus:E100075418_L01_9172_1
- GSM8576345 RNA-Seq of mus musculus:E100075418_L01_9173_1
- GSM8576346 RNA-Seq of mus musculus:E100075418_L01_9168_1
- GSM8576347 RNA-Seq of mus musculus:E100075418_L01_9169_1
- GSM8576348 RNA-Seq of mus musculus:E100075418_L01_9170_1
- GSM8576349 RNA-Seq of mus musculus:E100075418_L01_9174_1
- GSM8576350 RNA-Seq of mus musculus:E100075418_L01_9175_1
- GSM8576351 RNA-Seq of mus musculus:E100075418_L01_9178_1
- GSM8576352 RNA-Seq of mus musculus:E100075418_L01_9180_1
- GSM8576353 RNA-Seq of mus musculus:E100075418_L01_9176_1
- GSM8576354 RNA-Seq of mus musculus:E100075418_L01_9179_1
- GSM8576355 RNA-Seq of mus musculus:E18.5_6-1_KO_1
- GSM8576356 RNA-Seq of mus musculus:E100075418_L01_9177_1
- GSE279582 Adar1 as a placental innate immune rheostat to prevent endogenous dsRNA-induced integrated stress response-dependent embryonic lethality [Adar1 PKO RNA-seq] 14 samples shares adar1, response-dependent, dsrna-induced, endogenous, integrated, placental, embryonic, lethality
- GSE279053 Adar1 as a placental innate immune rheostat to prevent endogenous dsRNA-induced integrated stress response-dependent embryonic lethality 10 samples shares adar1, response-dependent, dsrna-induced, endogenous, integrated, placental, embryonic, lethality
- GSE124216 Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues 103 samples shares endogenous, embryonic
- GSE293177 A genome-wide screen reveals Ints7 deficiency activates endogenous retrovirus MERVL, accompanied by anastasis of embryonic stem cells [E14TG2a] 16 samples shares endogenous, embryonic
- GSE300876 A genome-wide screen reveals Ints7 deficiency activates endogenous retrovirus MERVL, accompanied by anastasis of embryonic stem cells [CUT&Tag] 12 samples shares endogenous, embryonic
- GSE234570 GGNBP2 regulates MDA5 sensing triggered by self double stranded RNA following loss of ADAR1 editing 95 samples shares adar1
- GSE233452 Fractionation of sgControl, sgIfih1 and sgGgnbp2 in HoxA9 immortalized Rosa26-CreERT2 Adar1fl/E861A immortalised myeloid cells. 54 samples shares adar1
- GSE87068 RNA Sequencing Quantitative Analysis of RNA editing sites of Wild Type and ADAR1 editing deficient (ADAR1E861A) murine fetal RNA of various tissues 43 samples shares adar1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.