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TNF Drives Aberrant BMP Signaling to Induce Endothelial and Mesenchymal Dysregulation in a Transgenic Model of Pulmonary Hypertension

GSE279244 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/11 Platform GPL24247
Summary
The pathobiology of pulmonary hypertension (PH) is complex and multiple cell types (endothelial, smooth muscle, fibroblast, pericyte) contribute to disease pathogenesis. However, the specific molecular crosstalk between endothelial and mesenchymal cells to promote PH is poorly characterized. We previously demonstrated that tumor necrosis factor alpha transgenic (TNF-Tg) mice have a severe PH phenotype.
Published in
TNF drives aberrant BMP signaling to induce endothelial and mesenchymal dysregulation in pulmonary hypertension
Garcia-Hernandez ML, Rangel-Moreno J, Xu Q et al. · JCI insight 2025 · PMID 40569693 · doi:10.1172/jci.insight.174456
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Also filed as BioProject PRJNA1171470 and SRA study SRP537817. Searching any of these in the dataset finder brings you back here.

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