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Cystathionine γ-lyase downregulation contributes to hepatocyte injury and dysfunction via multiple signaling pathways by regulation of histone lysine methylation

GSE279401 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/10/17 Platform GPL24247
Summary
Chronic liver disease (CLD) is prevalent globally. We sought to elucidate the molecular mechanisms governing the progress of CLD. We confirmed hepatic cystathionine γ-lyase (Cth) expression was significantly down-regulated in some CLDs. Therefore, we subsequently investigated the roles of Cth gene in the regulation of hepatic function and underlying mechanisms by using Cth knockout mice. Furthermore, we found that Cth deficiency resulted in one-carbon unit reprogramming, and betaine was one of key metabolites in one-carbon reprogramming, which caused changed histone lysine methylation and thereby leading to dysregulation of PPARα, PGC-1α, IRF8 and IRF9, the transcriptional factors governing metabolism, mitochondrial function and apoptosis. Our data immediately highlight a new potential target for therapy of some CLDs.
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Also filed as BioProject PRJNA1172652 and SRA study SRP538417. Searching any of these in the dataset finder brings you back here.

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