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VEGF-C treatment enhances meningeal lymphatic drainage after mild traumatic brain injury and protects against tau pathology, microgliosis and neurodegeneration in a mouse model of tau pathology.

GSE281850 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/26 Platform GPL13112

Summary

Traumatic brain injury (TBI) increases one’s risk of developing Alzheimer’s disease and tauopathy. Yet, the mechanisms linking TBI to neurodegenerative disease remain poorly defined. Mounting recent evidence indicates that defects in brain lymphatic drainage contribute to multiple neurodegenerative diseases. Here, we investigated whether promoting brain lymphatic drainage recuperation following TBI via treatment with the lymphangiogenic factor VEGFC mitigates the ability of TBI to exacerbate tauopathy. In this study, we show that a single mild TBI leads to worsened neuropathology, brain macrophage activation, and neurodegeneration in the PS19 mouse model of tauopathy. Moreover, we find that viral vector-based delivery of VEGFC into the meningeal compartment 24 hours post-TBI ameliorates tau-mediated neurodegenerative disease pathogenesis. Findings from these studies offer new insights into how TBI leads to the development of tauopathy later in life and suggest that VEGFC-based treatments might offer a therapeutic strategy to limit tauopathy after sustaining a head injury.

Published in

Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis

Royo Marco A, Bruch KR, Cowan MN et al. · Cell reports 2025 · PMID 41205178 · doi:10.1016/j.celrep.2025.116521

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Also filed as BioProject PRJNA1185816 and SRA study SRP545116. Searching any of these in the dataset finder brings you back here.

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