Targeting the Npy/Npy1r Signaling Axis in Mutant p53 Driven Pancreatic Cancer Impairs Metastasis
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 10 × KPR172HC_Npy1r_WT vs 10 × KPR172HC_Npy1r_KOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasisScience advances · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283652_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1194985 and SRA study SRP549759. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 2 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8668916 KPR172HC_Npy1r_WT_1 KPR172HC_Npy1r_WT
- GSM8668917 KPR172HC_Npy1r_WT_2 KPR172HC_Npy1r_WT
- GSM8668918 KPR172HC_Npy1r_WT_3 KPR172HC_Npy1r_WT
- GSM8668919 KPR172HC_Npy1r_WT_4 KPR172HC_Npy1r_WT
- GSM8668920 KPR172HC_Npy1r_WT_5 KPR172HC_Npy1r_WT
- GSM8668921 KPR172HC_Npy1r_WT_6 KPR172HC_Npy1r_WT
- GSM8668922 KPR172HC_Npy1r_WT_7 KPR172HC_Npy1r_WT
- GSM8668923 KPR172HC_Npy1r_WT_8 KPR172HC_Npy1r_WT
- GSM8668924 KPR172HC_Npy1r_WT_9 KPR172HC_Npy1r_WT
- GSM8668925 KPR172HC_Npy1r_WT_10 KPR172HC_Npy1r_WT
- GSM8668926 KPR172HC_Npy1r_KO_1 KPR172HC_Npy1r_KO
- GSM8668927 KPR172HC_Npy1r_KO_2 KPR172HC_Npy1r_KO
- GSM8668928 KPR172HC_Npy1r_KO_3 KPR172HC_Npy1r_KO
- GSM8668929 KPR172HC_Npy1r_KO_4 KPR172HC_Npy1r_KO
- GSM8668930 KPR172HC_Npy1r_KO_5 KPR172HC_Npy1r_KO
- GSM8668931 KPR172HC_Npy1r_KO_6 KPR172HC_Npy1r_KO
- GSM8668932 KPR172HC_Npy1r_KO_7 KPR172HC_Npy1r_KO
- GSM8668933 KPR172HC_Npy1r_KO_8 KPR172HC_Npy1r_KO
- GSM8668934 KPR172HC_Npy1r_KO_9 KPR172HC_Npy1r_KO
- GSM8668935 KPR172HC_Npy1r_KO_10 KPR172HC_Npy1r_KO
- GSE248585 A conserved epithelial wound-like transcriptional program driven by FOSL1 underlies malignant progression of pancreatic ductal adenocarcinoma (ssRNA-Seq) 46 samples shares pancreatic, driven
- GSE296071 Selective targeting of mutant huntingtin intron-1 improves rescue provided by antisense oligonucleotides in HTT.Q111/+ mice 30 samples shares targeting, mutant
- GSE324743 Hepatocytes promote liver metastasis of pancreatic cancer by providing exogenous serine 24 samples shares pancreatic, metastasis
- GSE251864 Optimization of a Mouse Model of Pancreatic Cancer to More Closely Simulate the Human Phenotypes of Metastasis and Cachexia 22 samples shares pancreatic, metastasis
- GSE287625 Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity 18 samples shares pancreatic, metastasis
- GSE275780 Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy [RNA-seq] 17 samples shares pancreatic, targeting
- GSE324997 Hepatocytes promote liver metastasis of pancreatic cancer by providing exogenous serine, 2. 16 samples shares pancreatic, metastasis
- GSE283198 Combined Flt3L and CD40 agonism restores dendritic cell driven T cell immunity in mouse models and patients with pancreatic cancer [mouse] 13 samples shares pancreatic, driven
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.