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Differential Enrichment of MAPK and Wnt Signaling Pathways in metastatic CRC tumors

GSE283935 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2026/01/08 Platform GPL24247
Summary
Colorectal cancer, a leading cause of cancer-related mortality due to distant metastases, is driven by activating mutations in the Wnt and MAPK pathways. Understanding the interplay between these crucial pathways during metastatic progression is essential for developing effective treatments. Here we developed an immunocompetent mouse model of metastatic colorectal cancer using in vivo orthotopic passaging. We demonstrate that highly metastatic tumor cells show increased MAPK activity, which in turn suppresses Wnt-associated transcriptional programs, including stem cell-associated genes.
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Direct links to NCBI, no account and no request form: the whole study as GSE283935_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1196354 and SRA study SRP550522. Searching any of these in the dataset finder brings you back here.

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