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Single cell profiling of CD11b+ cells from mouse cortex following astrocyte overexpression of mCherry-CAAX or Hevin

GSE289516 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/12 Platform GPL24247
Summary
Astrocyte derived Hevin regulates formation and maintenance of excitatory thalamocortical synapses in the developing mouse cortex. However, the role of astrocyte secreted factors on other cell types is still understudied. To interrogate the response of microglia to the release of astrocye derived Hevin, astrocytes were virally transduced with AAVs to overexpress Hevin or mCherry-CAAX.
Published in
Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinement
Ramirez JJ, Hardin EJ, Sakers K et al. · Neuron 2026 · PMID 41720089 · doi:10.1016/j.neuron.2025.12.028
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Also filed as BioProject PRJNA1223357 and SRA study SRP563721. Searching any of these in the dataset finder brings you back here.

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