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Effects of brown adipose tissue transplantation on post-myocardial infarction pathological remodeling

GSE291141 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/15 Platform GPL24247
Summary
Brown adipose tissue (BAT) is known to reduce the risk of metabolic and cardiovascular diseases. Here we demonstrate that BAT transplantation alleviates pathological cardiac remodeling and reduces the incidence of heart failure post-myocardial infarction (MI). RNA-seq profile of left ventricular tissue from BAT-transplanted mice at Day3 post-MI revealed downregulation of genes associated with pro-inflammatory innate immune cells and chemokines, suggesting reduced infiltration of innate immune cells (e.g., neutrophils) into the myocardium. Concurrently, genes involved in muscle cell differentiation and cardiac repair were upregulated. These results indicate that BAT promotes post-MI cardiac repair by suppressing innate immune cell recruitment, thereby improving cardiac outcomes.
Published in
Mitochondria-derived vesicles with bioenergetic units from brown adipose tissue attenuate cardiac remodeling post-myocardial infarction
Shi T, Chen F, Xu Y et al. · Nature communications 2026 · PMID 42168207 · doi:10.1038/s41467-026-73388-3
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Also filed as BioProject PRJNA1232077 and SRA study SRP568064. Searching any of these in the dataset finder brings you back here.

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