GEO series

Expression profile of mRNA involved in glucocorticoid-induced apoptosis in osteoblasts

GSE291858 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/21 Platform GPL17021

Summary

Further study on the mechanism of glucocorticoid (GC) -induced apoptosis of osteoblasts (OB) is of great practical significance for the prevention and treatment of steroid-induced osteoporosis and osteonecrosis. However, the regulatory mechanism of alternative splicing in GC-induced OB apoptosis remains unclear. The aim of this study is to explore the role and mechanism of the splicing regulator serine/arginine-rich splicing factor 1 (SRSF1) in GC-induced OB apoptosis. OBs were treated with 0.4mg/ml hydrocortisone, the active form of GC, for 12 hours, and the mRNA expression profile was obtained by RNA-seq. The key splicing factor SRSF1 mediating GC-induced OB apoptosis was successfully screened, and its role and regulatory mechanism were further determined. Importantly, overexpression of SRSF1 was resistant to GC-induced OB apoptosis.

Published in

Glucocorticoids regulate the expression of Srsf1 through Hdac4/Foxc1 axis to induce apoptosis of osteoblasts

Luo H, Wang T, Xie Z et al. · Communications biology 2025 · PMID 40186004 · doi:10.1038/s42003-025-07989-x

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Direct links to NCBI, no account and no request form: the whole study as GSE291858_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

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Also filed as BioProject PRJNA1235645 and SRA study SRP570208. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40186004) ↗

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