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Mechanisms of Activation and Serotonin release from Human Enterochromaffin Cells

GSE292419 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/02 Platform GPL24676
Summary
Gastrointestinal (GI) enterochromaffin (EC) cells are specialised sensors of luminal stimuli. They secrete most of the body’s serotonin (5-HT), and are critical for modulating GI motility, secretion, and sensation, while also signalling satiety and intestinal discomfort. The aim of this study was to investigate mechanisms underlying the regulation of human EC cells, and the relative importance of direct nutrient stimulation compared with neuronal and paracrine regulation.
Published in
Mechanisms of Activation and Serotonin Release From Human Enterochromaffin Cells
Alcaino C, Guccio N, Miedzybrodzka EL et al. · Cellular and molecular gastroenterology and hepatology 2025 · PMID 40812684 · doi:10.1016/j.jcmgh.2025.101610
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Also filed as BioProject PRJNA1238347 and SRA study SRP571669. Searching any of these in the dataset finder brings you back here.

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