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Progesterone receptor in uterine glands is required for pregnancy establishment in mice

GSE292591 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/03/26 Platform GPL21103
Summary
By utilizing Prss29-Cre, Pgr was conditionally deleted to identify the definitive roles of progesterone signaling in the uterine glands during pregnancy. This study provides new insights, demonstrating that PGR-P4 signaling in the glandular epithelium is required for uterine receptivity by regulating LIF on gestation day 4. Furthermore, we have shown that PGR signaling in glands is dispensable post-implantation.
Published in
Progesterone receptor in uterine glands is required for pregnancy establishment in mice
Bayammagari GS, Yeddula SGR, Winuthayanon S et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 · PMID 40123536 · doi:10.1096/fj.202500166RR
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Also filed as BioProject PRJNA1240265 and SRA study SRP572209. Searching any of these in the dataset finder brings you back here.

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