Effect of BAY2402234 treatment on gene expression in nasopharyngeal carcinoma C666-1 cells
RNA-seq (gene expression) · human · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Nasopharyngeal carcinomaThis series is part of our curated briefing on it.
- Samples
- 10 samples: 5 × C666-1, BAY vs 5 × C666-1, ctrlGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TP53-dependent antitumor effects of DHODH Inhibition in nasopharyngeal carcinomaDiscover oncology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE293574_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1245281 and SRA study SRP575957. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8885668 C666-1, BAY1 C666-1, BAY
- GSM8885669 C666-1, BAY2 C666-1, BAY
- GSM8885670 C666-1, BAY3 C666-1, BAY
- GSM8885671 C666-1, BAY4 C666-1, BAY
- GSM8885672 C666-1, BAY5 C666-1, BAY
- GSM8885673 C666-1, ctrl1 C666-1, ctrl
- GSM8885674 C666-1, ctrl2 C666-1, ctrl
- GSM8885675 C666-1, ctrl3 C666-1, ctrl
- GSM8885676 C666-1, ctrl4 C666-1, ctrl
- GSM8885677 C666-1, ctrl5 C666-1, ctrl
- GSE179224 A phase 2 Randomized Controlled Trial of Adjuvant Tumor-Infiltrating Lymphocytes for Pretreatment Epstein-Barr Virus DNA-selected High-Risk Nasopharyngeal Carcinoma Patients 4 samples same disease briefing · shares nasopharyngeal, treatment
- GSE120926 Single-cell RNA sequencing defines the interplay between tumor cells, virus and microenvironment in nasopharyngeal carcinoma 56 samples same disease briefing · shares nasopharyngeal
- GSE102349 Genomic Analysis of Nasopharyngeal Carcinoma Reveals TME-based Subtypes 113 samples same disease briefing · shares nasopharyngeal
- GSE305669 Reduced expression of UPF1 promotes tumor progression through stabilizing COX-2 mRNA in nasopharyngeal carcinoma 12 samples same disease briefing · shares nasopharyngeal
- GSE324767 RNA-Seq quantitative analysis of the regulatory effects of circRBM6 and circMLLT1 on nasopharyngeal carcinoma cell transcriptomes 8 samples same disease briefing · shares nasopharyngeal
- GSE231572 Development and validation of a microbiota signature to predict prognosis in nasopharyngeal carcinoma 64 samples same disease briefing · shares nasopharyngeal
- GSE234440 mRNA expression profiling of nasopharyngeal carcinoma cell line HONE1 upon ARNTL2 knockdown [RNA-seq] 6 samples same disease briefing · shares nasopharyngeal
- GSE302204 RNA-seq of Human nasopharyngeal carcinoma cells in BALF2-LR and BALF2-HR overexpress group 6 samples same disease briefing · shares nasopharyngeal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.