Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to ingested antigens
RNA-seq (gene expression) · mouse · 26 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 26 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to ingested antigensScience (New York, N.Y.) · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE293906_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1247394 and SRA study SRP576139. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 26 samples.
How we read this: 6 replicated groups read from 26 sample titles; they account for 26 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8885512 IEL, WT, rep1 IEL, WT,
- GSM8885513 IEL, WT, rep2 IEL, WT,
- GSM8885514 IEL, WT, rep3 IEL, WT,
- GSM8885515 IEL, WT, rep4 IEL, WT,
- GSM8885516 IEL, Het, rep5 IEL, Het,
- GSM8885517 IEL, Het, rep6 IEL, Het,
- GSM8885518 IEL, WT, rep7 IEL, WT,
- GSM8885519 IEL, WT, rep8 IEL, WT,
- GSM8885520 IEL, WT, rep9 IEL, WT,
- GSM8885521 IEL, WT, rep10 IEL, WT,
- GSM8885522 IEL, WT, rep11 IEL, WT,
- GSM8885523 LP, WT, rep1 LP, WT,
- GSM8885524 LP, WT, rep2 LP, WT,
- GSM8885525 LP, WT, rep3 LP, WT,
- GSM8885526 LP, WT, rep4 LP, WT,
- GSM8885527 LP, Het, rep5 LP, Het,
- GSM8885528 LP, Het, rep6 LP, Het,
- GSM8885529 LP, WT, rep7 LP, WT,
- GSM8885530 LP, WT, rep8 LP, WT,
- GSM8885531 LP, WT, rep9 LP, WT,
- GSM8885532 LP, WT, rep10 LP, WT,
- GSM8885533 LP, WT, rep11 LP, WT,
- GSM8893198 IEL_mast_cell, replicate 1 IEL_mast_cell,
- GSM8893199 LP_mast_cell, replicate 1 LP_mast_cell,
- GSM8893200 IEL_mast_cell, replicate 2 IEL_mast_cell,
- GSM8893201 LP_mast_cell, replicate 2 LP_mast_cell,
- GSE294512 eIF4G2-mediated Translation Initiation of Histone Modifiers is Essential for Intestinal Stem Cell Maintenance and Differentiation [RNA-seq] 92 samples shares intestinal, mediate
- GSE279403 Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22 28 samples shares cell-derived, intestinal
- GSE285771 Orai1 in pancreatic ductal cells mediates pancreas-intestinal crosstalk in experimental acute pancreatitis via the secretion of antimicrobial peptide REG3B in pancreatic juice 18 samples shares intestinal, mediate
- GSE280084 A Multipotent PROX1+ Tumor Cell Population Emerges During Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer 13 samples shares intestinal, mediate
- GSE291179 MyD88-mediated signaling in intestinal fibroblasts regulates macrophage antimicrobial defense and prevents dysbiosis in the gut I 10 samples shares intestinal, mediate
- GSE318069 eIF4G2-mediated Translation Initiation of Histone Modifiers is Essential for Intestinal Stem Cell Maintenance and Differentiation 145 samples shares intestinal, mediate
- GSE306673 Akkermansia muciniphila contributes to fasting-mediated radioprotection by inducing epigenetic and transcriptional changes in small intestinal epithelial cells 32 samples shares intestinal, mediate
- GSE318068 eIF4G2-mediated Translation Initiation of Histone Modifiers is Essential for Intestinal Stem Cell Maintenance and Differentiation [Multiome] 16 samples shares intestinal, mediate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.