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Bulk RNA-seq profiling of mouse livers with Themis ablation under MASH diet feeding condition

GSE300143 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/10 Platform GPL24247
Summary
Metabolic dysfunction-associated steatohepatitis (MASH) is a severe chronic liver condition characterized by hepatocyte steatosis, inflammation and fibrosis, with a rising prevalence globally, posing significant health risks and potentially leading to complications such as cirrhosis, liver failure, and increased mortality. Previous study in our lab has identified Themis as a highly up-regulated gene in hepatocytes during MASH progression using a diet-induced mouse model. Genetic ablation of Themis exacerbated MASH symptoms, including more severe steatosis, liver injury, fibrosis and more immune cell infiltration.
Published in
THEMIS attenuates MASH by suppressing disease-associated hepatocyte induction and hepatocyte senescence in mice
Qiu X, Lu Y, Tang Y et al. · The Journal of clinical investigation 2026 · PMID 42065240 · doi:10.1172/JCI199303
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Also filed as BioProject PRJNA1279123 and SRA study SRP592939. Searching any of these in the dataset finder brings you back here.

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