The kinase PLK1 promote melanoma progression in the BRAFV600E/PTEN-deficient mouse
RNA-seq (gene expression) · mouse · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples: 6 × PLK1 wt tumo vs 5 × PLK1-overexpressed tumoGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1PLoS biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301421_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1284959 and SRA study SRP596514. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 5 samples read as cases, 6 as controls.
How we read this: 2 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9083069 PLK1 wt tumor 4957 PLK1 wt tumo
- GSM9083070 PLK1 wt tumor 4971 PLK1 wt tumo
- GSM9083071 PLK1 wt tumor 0007 PLK1 wt tumo
- GSM9083072 PLK1 wt tumor 0002 PLK1 wt tumo
- GSM9083073 PLK1 wt tumor 4949 PLK1 wt tumo
- GSM9083074 PLK1 wt tumor 4958 PLK1 wt tumo
- GSM9083075 PLK1-overexpressed tumor 0001 PLK1-overexpressed tumo
- GSM9083076 PLK1-overexpressed tumor 0006 PLK1-overexpressed tumo
- GSM9083077 PLK1-overexpressed tumor 4975 PLK1-overexpressed tumo
- GSM9083078 PLK1-overexpressed tumor 4976 PLK1-overexpressed tumo
- GSM9083079 PLK1-overexpressed tumor 4980 PLK1-overexpressed tumo
- GSE203467 COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway [NGS2569] 12 samples shares brafv600e, melanoma
- GSE263358 Chromatin Modification Abnormalities by CHD7 and KMT2C Loss Promote Medulloblastoma Progression [RNA-seq] 21 samples shares progression, promote
- GSE261845 Targeting melanoma cell-intrinsic beta2 integrin inhibits ICAM-1-mediated tumor progression 20 samples shares progression, melanoma
- GSE311895 Stiffness-related mitochondria transfer promotes tumor progression through metabolic reprogramming 18 samples shares progression, promote
- GSE271194 Effect of genetic modification of extracellular matrix-related genes on B16F1 melanoma progression 15 samples shares progression, melanoma
- GSE328178 Genetic suppression of myeloid receptor Clec7a attenuates microglia neuroinflammation and promotes microglial phagocytosis to delay disease progression in ALS models 14 samples shares progression, promote
- GSE274650 G3BP1 translocates into mitochondria to impair MCU complex function and promotes NASH progression [G3bp1-HKO and G3bp1-Flox mice with BSA or PA treatment] 12 samples shares progression, promote
- GSE283887 Piezo1 promotes the progression of necrotizing enterocolitis via activating Ca2(+)/CaMKII-dependent pathway 12 samples shares progression, promote
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.