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Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia [RNA-Seq]

GSE303946 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/01/27 Platform GPL17021
Summary
Alkaloid febrifugine., an herbal medicine in China, is prescribed routinely for malaria treatment. Halofuginone (HF), a natural product isolated from alkaloid febrifugine, exhibits anti-tumor and anti-inflammatory ability. Aim of the study: Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy with low overall survival (OS). Resistance to chemotherapeutic drugs such as idarubicin (IDA) results in treatment failure. This study investigated the role of HF in anti-AML ability and in overcoming IDA resistance in AML cells.
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Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia
Shi L, Zhao M, Meng C et al. · Chinese medicine 2026 · PMID 41491331 · doi:10.1186/s13020-025-01278-9
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Also filed as BioProject PRJNA1298286 and SRA study SRP604403. Searching any of these in the dataset finder brings you back here.

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