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Retinoic Acid-Mediated Signaling Regulates Allantoic and Fetoplacental Vascularization

GSE304388 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/17 Platform GPL30172
Summary
The placenta is vital for fetal development, and altered placental vascularization underlies prevalent disorders, including fetal growth restriction, prematurity, and pregnancy complications. Impaired placental vascularization is associated with Vitamin A deficiency, but mechanisms are undefined. To investigate this, we used retinoic acid (RA)-deficient Raldh2⁻/⁻ embryos, and found they exhibit placental endothelial hyperproliferation and impaired arterial-venous remodeling, which were rescued by providing all‑trans‑RA (ATRA) via maternal diet. Single cell RNA sequencing of E9.5 Raldh2+/+, Raldh2⁻/⁻,and Raldh2⁻/⁻+ATRA placental cells, and functional assays, revealed that RA regulates endothelial growth and vascular remodeling via Notch signaling.
Published in
Retinoic acid regulates fetoplacental vascularization via notch signaling and a SEMA3E/F-PLEXIND1 axis
Cwiek A, Paila U, Markowska Z et al. · iScience 2026 · PMID 41884003 · doi:10.1016/j.isci.2026.115205
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Also filed as BioProject PRJNA1301236 and SRA study SRP606291. Searching any of these in the dataset finder brings you back here.

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