BM-MSC-Derived Migrasomes Reverse Stroke-Induced Thymic Atrophy and Immunosuppression via Pin1 Delivery to Thymic Epithelial Cells
Single-cell RNA-seq · mouse · 15 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 5 × adult male thymus Veh vs 5 × adult male thymus BM-MSC vs 5 × adult male thymus MigrasomeGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- BM-MSC-derived migrasomes reverse stroke-induced thymic atrophy and immunosuppression via Pin1 delivery to thymic epithelial cellsJournal of neuroinflammation · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE305141_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1303858 and SRA study SRP607800. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 3 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9162716 BulkRNA-seq of mus musculus: adult male thymus Veh1 adult male thymus Veh
- GSM9162717 BulkRNA-seq of mus musculus: adult male thymus Veh2 adult male thymus Veh
- GSM9162718 BulkRNA-seq of mus musculus: adult male thymus Veh3 adult male thymus Veh
- GSM9162719 BulkRNA-seq of mus musculus: adult male thymus Veh4 adult male thymus Veh
- GSM9162720 BulkRNA-seq of mus musculus: adult male thymus BM-MSC1 adult male thymus BM-MSC
- GSM9162721 BulkRNA-seq of mus musculus: adult male thymus BM-MSC2 adult male thymus BM-MSC
- GSM9162722 BulkRNA-seq of mus musculus: adult male thymus BM-MSC3 adult male thymus BM-MSC
- GSM9162723 BulkRNA-seq of mus musculus: adult male thymus BM-MSC4 adult male thymus BM-MSC
- GSM9162724 BulkRNA-seq of mus musculus: adult male thymus Migrasome1 adult male thymus Migra…
- GSM9162725 BulkRNA-seq of mus musculus: adult male thymus Migrasome2 adult male thymus Migra…
- GSM9162726 BulkRNA-seq of mus musculus: adult male thymus Migrasome3 adult male thymus Migra…
- GSM9162727 BulkRNA-seq of mus musculus: adult male thymus Migrasome4 adult male thymus Migra…
- GSM9162728 scRNA-seq of mus musculus: adult male thymus Veh1 adult male thymus Veh
- GSM9162729 scRNA-seq of mus musculus: adult male thymus BM-MSC1 adult male thymus BM-MSC
- GSM9162730 scRNA-seq of mus musculus: adult male thymus Migrasome1 adult male thymus Migra…
- GSE266110 7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas 40 samples shares immunosuppression, reverse
- GSE189382 Epithelial deletion of CUL4B increased myeloid-derived suppressor cells-mediated immunosuppression to promote ApcMin/+ tumor formation 12 samples shares immunosuppression, epithelial
- GSE254221 ITGAV in PBMCs is identified as a hub gene in oxidative stress-related immunosuppression and delayed burn wound healing and is reversed by MnCl2 10 samples shares immunosuppression, reverse
- GSE325102 CXCL6 exacerbates metabolic dysfunction-associated steatohepatitis by suppressing LPIN1-mediated fatty acid oxidation in hepatocytes 12 samples shares pin1
- GSE268241 HPV16-expressing tumors release multiple IL-1 ligands to orchestrate systemic immunosuppression whose disruption enables efficacy of a therapeutic vaccine. 63 samples shares immunosuppression
- GSE196790 Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk promoting immunosuppression and immunotherapy resistance 54 samples shares immunosuppression
- GSE301030 Inhibiting B-cell-mediated Immunosuppression to Enhance the Immunotherapy Efficacy in Hepatocellular Carcinoma 54 samples shares immunosuppression
- GSE90497 Steatohepatitis progresses to cancer via immunosuppression of HCC directed CD8+ T cells 41 samples shares immunosuppression
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.