Transcriptomic adaptations of human muscle after short- and long-term exercise
RNA-seq (gene expression) · human · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 13 samples: 4 × Muscle, control, vs 3 × Muscle, 24 hours post-exercise, vs 3 × Muscle, post-6 weeks of exercise, Patient vs 3 × Muscle, pre-exercise training, PatientGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophyDevelopmental cell · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE312393_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1373228 and SRA study SRP651077. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 6 samples read as cases, 4 as controls.
How we read this: 4 replicated groups read from 13 sample titles; they account for 13 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9344919 Muscle, control, rep1 Muscle, control,
- GSM9344920 Muscle, control, rep2 Muscle, control,
- GSM9344921 Muscle, control, rep3 Muscle, control,
- GSM9344922 Muscle, control, rep4 Muscle, control,
- GSM9344923 Muscle, 24 hours post-exercise, rep1 Muscle, 24 hours post-e…
- GSM9344924 Muscle, 24 hours post-exercise, rep2 Muscle, 24 hours post-e…
- GSM9344925 Muscle, 24 hours post-exercise, rep3 Muscle, 24 hours post-e…
- GSM9344926 Muscle, post-6 weeks of exercise, Patient 11 Muscle, post-6 weeks of…
- GSM9344927 Muscle, post-6 weeks of exercise, Patient 16 Muscle, post-6 weeks of…
- GSM9344928 Muscle, post-6 weeks of exercise, Patient 9 Muscle, post-6 weeks of…
- GSM9344929 Muscle, pre-exercise training, Patient 11 Muscle, pre-exercise tr…
- GSM9344930 Muscle, pre-exercise training, Patient 16 Muscle, pre-exercise tr…
- GSM9344931 Muscle, pre-exercise training, Patient 9 Muscle, pre-exercise tr…
- GSE97084 Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans 103 samples shares adaptations, exercise
- GSE311567 Transcriptomic adaptations of human muscle in patients with polyarteritis nodosa and muscle denervation 13 samples shares adaptations, muscle
- GSE330697 Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle 93 samples shares exercise, muscle
- GSE252357 The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates MYC as a Hypertrophic Regulator 61 samples shares exercise, muscle
- GSE263838 The interactive effect of sustained sleep restriction and resistance exercise on skeletal muscle transcriptomics in young females 38 samples shares exercise, muscle
- GSE324210 Exercise Training Attenuates the Monocyte Transcriptome Response to Acute Exercise in Adolescents: Evidence for Sex-Specific Molecular Adaptations 83 samples shares adaptations, exercise
- GSE240061 Integrated single-cell multiome analysis resolves muscle fiber-type gene regulatory circuitry modulated by endurance exercise 40 samples shares exercise, muscle
- GSE276889 Mitochondria isolated from male skeletal muscle contain a small and distinct population of microRNA that are differentially expressed following acute endurance exercise 33 samples shares exercise, muscle
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.