GEO series
Urolithin A attenuates inflammation and enhances barrier integrity in an experimental NEC-in-a-Dish model
GSE312490
Homo sapiens
Expression profiling by high throughput sequencing
44 samples
2026/05/27
GPL34281
Summary
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease in preterm infants, characterized by exaggerated inflammation and poorly understood pathogenesis. Aryl hydrocarbon receptor (AhR) signaling has been shown to reduce intestinal inflammation in colitis models. In these models, a microbial-derived AhR ligand, Urolithin A (UroA), has demonstrated anti-inflammatory properties and improved gut barrier function. We hypothesize that UroA attenuates inflammation and enhances epithelial barrier integrity in an in vitro NEC-in-a-Dish model.
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