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MIZ-1 (c-Myc-interacting Zinc Finger Protein-1, ZBTB17) is required for efficient B cell receptor signaling [RNA-seq]

GSE313263 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/04/15 Platform GPL13112
Summary
B cell receptor (BCR) signaling is required for the regulation of normal B lymphocyte development. We found that mice expressing a POZ domain-deficient MIZ-1 (MIZ-1ΔPOZ) exhibit impaired BCR signaling. Transcriptomic and ChIP-seq analyses reveal that, in addition to autophagy related genes, MIZ-1 directly regulates genes involved in BCR signaling and actin cytoskeleton dynamics.
Published in
MIZ-1 controls transcriptional programs required for BCR signaling, actin dynamics, and naïve B cell survival
Ross J, Piskor EM, Joly-Beauparlant C et al. · Frontiers in immunology 2026 · PMID 41972179 · doi:10.3389/fimmu.2026.1758550
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Also filed as BioProject PRJNA1378848 and SRA study SRP654091. Searching any of these in the dataset finder brings you back here.

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