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Inhibition of P2RX7 Protects Against Light-Induced Retinal Degeneration by Suppressing cGAS-STING Signaling I

GSE314042 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/16 Platform GPL34290
Summary
Using comprehensive transcriptomic data, this approach objectively and quantitatively links observable pathological phenomena (light damage, cell death) with underlying molecular mechanisms (activation of DNA damage pathways and innate immune pathways). Thereby, it uncovers the intrinsic logic of disease development and progression, providing the most direct molecular basis for identifying therapeutic targets (such as the STING protein).
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Direct links to NCBI, no account and no request form: the whole study as GSE314042_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1379259 and SRA study SRP654258. Searching any of these in the dataset finder brings you back here.

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