Beta3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
RNA-seq (gene expression) · mouse
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Neutrophils preserve energy storage in sympathetically activated adipocytesNature · 2026
Read the full summary ↓
Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need.
Whole study · RAW.tar
Everything the authors deposited as one archive (GSE315788_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
- GSE290031 Very long-chain ceramides in skeletal muscle associate with systemic insulin resistance independent of obesity 92 samples shares resistance, obesity
- GSE275147 A catecholamine-independent pathway controlling adaptive adipocyte lipolysis 79 samples shares catecholamine, adipocyte
- GSE286275 Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes 38 samples shares resistance, adipocyte
- GSE254704 Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice 32 samples shares resistance, obesity
- GSE264369 Fatty acid oxidation downregulation in alveolar epithelial 2 cells promotes acute lung injury in obesity 18 samples shares downregulation, obesity
- GSE246877 Steroid receptor coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress 12 samples shares resistance, receptor
- GSE289421 Estrogen Receptor 1 Signaling in Hepatic Stellate Cells Designates Resistance to Liver Fibrosis [ChIP-seq] 14 samples shares resistance, receptor
- GSE284365 IRE1α Downregulation Enhances STING-Mediated Chemoresistance and Guides Precision Therapies in Pancreatic Cancer 12 samples shares downregulation, resistance
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.