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Long-term effects of adolescent risperidone treatment on mouse cortex

GSE316091 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/07/14 Platform GPL30172
Summary
Antipsychotics have been increasingly prescribed for children and adolescents. Despite multiple rodent studies showing long-term neurocognitive dysfunction associated with adolescent antipsychotic treatment, there is a lack of understanding of neurobiological underpinnings of these long-term changes. We utilized single nucleus RNA-seq to assess the long-term transcriptomic changes in mouse cortex, 9 weeks after they were treated with risperidone during adolescence. Analysis of the mouse cortex snRNA-seq dataset showed downregulation in voltage-gated and inwardly rectifying potassium channels and genes associated with synaptic structure and function in pyramidal neurons and interneurons. Our findings suggest that adolescent risperidone treatment can cause long-term transcriptomic changes associated with altered excitatory-inhibitory neuronal interactions.
Published in
Long-term effects of adolescent risperidone treatment on the mouse cortex
Alicea-Pauneto AD, Choi H, Zhang W et al. · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2026 · PMID 42420423 · doi:10.1038/s41386-026-02483-2
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Also filed as BioProject PRJNA1400582 and SRA study SRP661073. Searching any of these in the dataset finder brings you back here.

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