TET1 non-catalytic activity shapes the chromatin-landscape that directs de novo methylation establishment in the male germline
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 44 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 44 samples: 10 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TET1 noncatalytic activity shapes the chromatin landscape associated with de novo methylation establishment in the male germlineGenes & development · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE318256_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1416980 and SRA study SRP672365. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 42 samples.
How we read this: 10 replicated groups read from 44 sample titles; they account for 42 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9491399 E17_H3K4me3_KO1 E17_H3K4me3_KO
- GSM9491400 E17_H3K4me3_KO2 E17_H3K4me3_KO
- GSM9491401 E17_H3K4me3_KO3 E17_H3K4me3_KO
- GSM9491402 E17_H3K4me3_HxD1 E17_H3K4me3_HxD
- GSM9491403 E17_H3K4me3_HxD2 E17_H3K4me3_HxD
- GSM9491404 E17_H3K4me3_HxD3 E17_H3K4me3_HxD
- GSM9491405 E17_H3K4me3_WT1 E17_H3K4me3_WT
- GSM9491406 E17_H3K4me3_WT2 E17_H3K4me3_WT
- GSM9491407 E17_H3K4me3_WT3 E17_H3K4me3_WT
- GSM9491408 E17_IGG_KO1 E17_IGG_KO
- GSM9491409 E17_IGG_KO2 E17_IGG_KO
- GSM9491410 E17_IGG_KO3 E17_IGG_KO
- GSM9491411 E17_IGG_HxD1 E17_IGG_HxD
- GSM9491412 E17_IGG_HxD2 E17_IGG_HxD
- GSM9491413 E17_IGG_HxD3 E17_IGG_HxD
- GSM9491414 E17_IGG_WT1 E17_IGG_WT
- GSM9491415 E17_IGG_WT2 E17_IGG_WT
- GSM9491416 E17_IGG_WT3 E17_IGG_WT
- GSM9491417 E17.5 Prospermatogonia KO 1 E17.5 Prospermatogonia …
- GSM9491418 E17.5 Prospermatogonia KO 2 E17.5 Prospermatogonia …
- GSM9491419 E17.5 Prospermatogonia KO 3 E17.5 Prospermatogonia …
- GSM9491420 E17.5 Prospermatogonia KO 4 E17.5 Prospermatogonia …
- GSM9491421 E17.5 Prospermatogonia WT 1 E17.5 Prospermatogonia …
- GSM9491422 E17.5 Prospermatogonia WT 2 E17.5 Prospermatogonia …
- GSM9491423 E17.5 Prospermatogonia WT 3 E17.5 Prospermatogonia …
- GSM9491424 E17.5 Prospermatogonia WT 4 E17.5 Prospermatogonia …
- GSM9491425 spg_5hmC
- GSM9491426 input-spg_5hmC
- GSM9511523 E13.5 PGC KO-1 E13.5 PGC KO
- GSM9511524 E13.5 PGC KO-2 E13.5 PGC KO
- GSM9511526 E13.5 PGC KO-3 E13.5 PGC KO
- GSM9511527 E13.5 PGC KO-4 E13.5 PGC KO
- GSM9511528 E13.5 PGC KO-5 E13.5 PGC KO
- GSM9511529 E13.5 PGC KO-6 E13.5 PGC KO
- GSM9511530 E13.5 PGC KO-7 E13.5 PGC KO
- GSM9511531 E13.5 PGC KO-8 E13.5 PGC KO
- GSM9511532 E13.5 PGC WT-1 E13.5 PGC WT
- GSM9511533 E13.5 PGC WT-2 E13.5 PGC WT
- GSM9511534 E13.5 PGC WT-3 E13.5 PGC WT
- GSM9511535 E13.5 PGC WT-4 E13.5 PGC WT
+ 4 more — browse all 44 samples with per-sample file links →
- GSE318253 TET1 non-catalytic activity shapes the chromatin-landscape that directs de novo methylation establishment in the male germline [CUTandRUN] 18 samples shares tet1, chromatin-landscape, non-catalytic, establishment, methylation, activity, germline, directs
- GSE318254 TET1 non-catalytic activity shapes the chromatin-landscape that directs de novo methylation establishment in the male germline [RNAseq] 8 samples shares tet1, chromatin-landscape, non-catalytic, establishment, methylation, activity, germline, directs
- GSE24843 Tet1 and hydroxymethylcytosine in transcription and DNA methylation fidelity 32 samples shares tet1, methylation
- GSE24841 Tet1 and hydroxymethylcytosine in transcription and DNA methylation fidelity (ChIP/DIP-Seq data) 17 samples shares tet1, methylation
- GSE24842 Tet1 and hydroxymethylcytosine in transcription and DNA methylation fidelity (Affymetrix gene expression data) 15 samples shares tet1, methylation
- GSE271376 TET1 Displays Catalytic and Non-catalytic Functions in the Adult Mouse Cortex [RNA-seq] 12 samples shares tet1, non-catalytic
- GSE264193 H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos [ChIP-seq] 57 samples shares establishment, methylation
- GSE306634 DOT1L-mediated H3K79me2 directs B-cell repertoire establishment, marginal zone development and germinal center function 21 samples shares establishment, directs
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.