GEO series
RNA-seq analysis of B16F10 cells following p300/CBO knockout
GSE318796
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2026/04/29
GPL24247
Summary
The p300 and CBP (CREB-binding protein) paralogs are essential histone acetyltransferases (HATs) that serve as global transcriptional coactivators. In many cancers, including melanoma, these proteins redundantly regulate key oncogenic and lineage-specific gene programs. To investigate their combined role in melanoma, we generated p300/CBP sinlge and double-knockout (dKO) B16F10 murine melanoma cells using CRISPR/Cas9. We then performed bulk RNA-sequencing to identify genes and biological pathways that are critically dependent on these coactivators. Our results define the shared and unique transcriptional targets of p300/CBP in the B16F10 model and provide a resource for understanding how their loss impacts melanoma cell fitness, invasive potential, and stress responses.
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