← BioTransfer GEO Dataset Finder
GEO series

Glucocorticoid eceptor dimerization in tumorigenesis

GSE319965 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/20 Platform GPL24247
Summary
Glucocorticoids exert prominent effects in the colon, yet the role of glucocorticoid receptor (GR) dimerization remains unclear. AOM/DSS-induced tumorigenesis in GRdim mice harboring a predominantly monomeric GR was investigated. Monomeric GR activities in tumorigenesis followed a biphasic pattern. GRdim mice exhibited a delayed tumor onset and prolonged survival, yet tumors that did develop progressed more rapidly and grew larger. The distinct inflammatory gene signature in GRdim tumors resulted in impaired recruitment and activation of neutrophils and inflammatory macrophages, with Il1b as the central hub gene. GRdim tumor signature overlapped with genes dysregulated in human colorectal cancer and correlated with poor patient survival, thus mimicking the murine tumor model.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE319965_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1425796 and SRA study SRP678172. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.