GEO series
Effect of depletion of Nsd1 or Ezh2 on gene expression during pluripotency transition
GSE334791
Mus musculus
Expression profiling by high throughput sequencing
8 samples
2026/07/15
GPL13112
Summary
CRISPR Screen with single-cell RNA-Seq as readout reveals new epigenetic factors regulate pluripotency of m ESCs. This highly sensitive method identified key genes essential for the acquisition and exit from pluripotency, and revealed loss of Nsd1-mediated H3K36me2 delayed exit from the naive state, while loss of Ezh2-mediated H3K27me3 promoted transition to the primed state.
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