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Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion

GSE65000 Mus musculus; Homo sapiens Expression profiling by high throughput sequencing 36 samples Submitted 2015/03/02 Platform GPL11154Platform GPL13112
Summary
The evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Here, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a novel approach from developing mouse and human neocortex. We identify 56 genes preferentially expressed in human apical and basal radial glia that lack mouse orthologs. Among these, ARHGAP11B has the highest degree of radial glia-specific expression. ARHGAP11B arose from partial duplication of the Rho GTPase-activating-protein–encoding ARHGAP11A on the human lineage after separation from the chimpanzee lineage. Expression of ARHGAP11B in embryonic mouse neocortex promotes basal progenitor generation and self-renewal, and can increase cortical plate area and induce gyrification. Hence, ARHGAP11B may have contributed to evolutionary expansion of human neocortex.
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Also filed as BioProject PRJNA272678 and SRA study SRP052294. Searching any of these in the dataset finder brings you back here.

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