NOTCH1 across 8 cancers
NOTCH1 is on the target list of 8 of the briefings. No drug aimed at it carries an FDA label naming any of them. In the reference cohorts of the 8 with a mutation landscape it is altered in at least 5% of patients in 6 and in under 2% in 2 (Acute lymphoblastic leukemia, Mantle cell lymphoma) — a target there by expression, dependency or drug label, not by mutation.
| Disease | Label status | Furthest stage (Open Targets) | Distinct drugs | Cell-therapy trials | Altered in the reference cohort |
|---|---|---|---|---|---|
| Acute lymphoblastic leukemia | phase 1 | 1 | — | 0.0% mut · 1.76% amp · 1.32% del n=137 | |
| Chronic lymphocytic leukemia | phase 1 | 1 | — | 5.03% mut n=1074 | |
| Cutaneous squamous cell carcinoma | phase 1 | 1 | — | 55.42% mut n=83 | |
| Head and neck cancer | phase 1 | 1 | — | 17.09% mut · 0.77% amp · 1.74% del n=515 | |
| Lower-grade glioma | phase 1 | 1 | — | 7.39% mut · 1.37% amp · 0.2% del n=514 | |
| Mantle cell lymphoma | phase 1 | 1 | — | 0.0% mut n=29 | |
| Merkel cell carcinoma | phase 1 | 1 | — | 11.97% mut n=142 | |
| Vulvar cancer | phase 1 | 1 | — | 13.33% mut n=15 |
"Approved here" means a drug Open Targets records as aimed at NOTCH1 carries an FDA label that names that disease, per the briefing's openFDA stage. "Approved elsewhere" means the drug is approved for some other indication. Stage is the furthest Open Targets clinical stage among drugs aimed at the gene, in any indication; the database is reported as it is, and it lags some approvals. Cell-therapy trials are counted on the antigen the briefing maps the gene to, from ClinicalTrials.gov. The last column is the disease's mutation landscape: non-silent mutation, high-level amplification and deep deletion as percentages of the reference cohort's patients, each over its own denominator; "not on panel" means the reference cohort could not have called the gene.