The Human Milk Oligosaccharide 3’Sialyllactose Promotes Inflammation Resolution and Reduces Atherosclerosis Development in Mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The human milk oligosaccharide 3'sialyllactose reduces low-grade inflammation and atherosclerosis development in miceJCI insight · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE167999_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA705731 and SRA study SRP308740. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 12 more — browse all 12 samples with per-sample file links →
- GSE319030 Macrophage EHD1 promotes inflammation and stabilizes sortilin to accelerate atherosclerosis 14 samples shares atherosclerosis, promotes
- GSE289751 Resolution of inflammation in imprinted fibroblast-like synoviocytes establishes a transcriptomic signature that promotes endothelial cell dysfunction. 12 samples shares resolution, promotes
- GSE319027 Macrophage EHD1 promotes inflammation and stabilizes sortilin to accelerate atherosclerosis [RNA-Seq] 12 samples shares atherosclerosis, promotes
- GSE312987 Effects of dietary human milk oligosaccharides (HMO) and Trichuiris muris (Tm) infection on the caecum transcriptome in mice 30 samples shares oligosaccharide, milk
- GSE210460 Time-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice 24 samples shares atherosclerosis, reduces
- GSE309959 Neutrophil-induced lipoxygenase subtype promotes resolution of acute lung injury in mice 10 samples shares resolution, promotes
- GSE319375 Trained immunity of alveolar macrophages promotes injury resolution by enhancing KLF4-MERTK-mediated efferocytosis [2] 18 samples shares resolution, promotes
- GSE316135 ADAMTS7 promotes smooth muscle foam cell expansion in atherosclerosis 10 samples shares atherosclerosis, promotes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.