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Comparison of total and polyribosome-associated mRNA levels in male Fmr1 KO mice and male WT littermates

GSE26745 Mus musculus Expression profiling by array 24 samples Submitted 2011/07/21 Platform GPL1261
Summary
The Fragile X Mental Retardation Protein, FMRP, is thought to regulate the translation of a specific set of neuronal mRNAs on polyribosomes. Therefore, we prepared polyribosomes on sucrose gradients and purified mRNA specifically from these fractions, as well as the total mRNA levels, to determine whether a set of mRNAs might be changed in its % association with polyribosomes in the absence of FMRP in the KO mouse model. No significant differences were found, other than the Fmr1 transcript itself, in total mRNA levels or % polyribosome association that withstood multiple test correction, in P7 Fmr1 KO mouse cerebral cortex compared with WT littermates..
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Also filed as BioProject PRJNA142133. Searching any of these in the dataset finder brings you back here.

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