Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study
RNA-seq (gene expression) · human · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Endometrial cancerThis series is part of our curated briefing on it.
- Samples
- 10 samples: 10 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I studyNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE268903_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1119430 and SRA study SRP511345. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 10 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8302395 PAM007, CD8 T cells, scRNAseq
- GSM8302396 PAM007, CD4 T cells, scRNAseq
- GSM8302397 PAM010, CD8 T cells, scRNAseq
- GSM8302398 PAM010, CD4 T cells, scRNAseq
- GSM8302399 PAM011, CD3 T cells, scRNAseq
- GSM8302400 PAM007, CD8 T cells, scTCRseq
- GSM8302401 PAM007, CD4 T cells, scTCRseq
- GSM8302402 PAM010, CD8 T cells, scTCRseq
- GSM8302403 PAM010, CD4 T cells, sTCRseq
- GSM8302404 PAM011, CD3 T cells, scTCRseq
- GSE212217 Distinct Mechanisms of Mismatch-Repair Deficiency Delineate Two Modes of Response to Anti–PD-1 Immunotherapy in Endometrial Carcinoma 104 samples same disease briefing · shares endometrial, mismatch, repair
- GSE247793 Cell cycle checkpoint proficiency of endometrial cancer cells 42 samples same disease briefing · shares endometrial, checkpoint
- GSE306395 A very low carbohydrate, ketogenic diet suppresses tumor insulin signaling and enhances immune infiltration in women with endometrial cancer: results from a randomized feasibility study. 16 samples same disease briefing · shares endometrial, women
- GSE323968 Transcriptional signatures indicating RB function may predict response to CDK4/6 inhibition in endometrial cancer 56 samples same disease briefing · shares endometrial
- GSE307568 Patient-derived organoid – immune cell co-culture platform for therapeutics discovery in high-grade endometrial cancer 189 samples same disease briefing · shares endometrial
- GSE17025 Gene Expression Analysis of Stage I Endometrial Cancers 103 samples same disease briefing · shares endometrial
- GSE323965 Transcriptional signatures indicating RB function may predict response to CDK4/6 inhibition in endometrial cancer [RNA-Seq] 39 samples same disease briefing · shares endometrial
- GSE312906 Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer 37 samples same disease briefing · shares endometrial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.