The pivotal role of the Hes1–Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosis
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 5 × tibia, vehicle control, vs 5 × tibia, vehicle loading, vs 5 × tibia, DEX control, vs 5 × tibia, DEX loading,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The pivotal role of the Hes1/Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosisJCI insight · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276391_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1157197 and SRA study SRP530561. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8497707 tibia, vehicle control, 1 tibia, vehicle control,
- GSM8497708 tibia, vehicle control, 2 tibia, vehicle control,
- GSM8497709 tibia, vehicle control, 3 tibia, vehicle control,
- GSM8497710 tibia, vehicle control, 4 tibia, vehicle control,
- GSM8497711 tibia, vehicle control, 5 tibia, vehicle control,
- GSM8497712 tibia, vehicle loading, 1 tibia, vehicle loading,
- GSM8497713 tibia, vehicle loading, 2 tibia, vehicle loading,
- GSM8497714 tibia, vehicle loading, 3 tibia, vehicle loading,
- GSM8497715 tibia, vehicle loading, 4 tibia, vehicle loading,
- GSM8497716 tibia, vehicle loading, 5 tibia, vehicle loading,
- GSM8497717 tibia, DEX control, 1 tibia, DEX control,
- GSM8497718 tibia, DEX control, 2 tibia, DEX control,
- GSM8497719 tibia, DEX control, 3 tibia, DEX control,
- GSM8497720 tibia, DEX control, 4 tibia, DEX control,
- GSM8497721 tibia, DEX control, 5 tibia, DEX control,
- GSM8497722 tibia, DEX loading, 1 tibia, DEX loading,
- GSM8497723 tibia, DEX loading, 2 tibia, DEX loading,
- GSM8497724 tibia, DEX loading, 3 tibia, DEX loading,
- GSM8497725 tibia, DEX loading, 4 tibia, DEX loading,
- GSM8497726 tibia, DEX loading, 5 tibia, DEX loading,
- GSE298695 Mechanosensing by endothelial Piezo1 promotes liver regeneration after partial hepatectomy via ATF2-ID1-Wnt2 pathway 16 samples shares piezo1
- GSE283887 Piezo1 promotes the progression of necrotizing enterocolitis via activating Ca2(+)/CaMKII-dependent pathway 12 samples shares piezo1
- GSE287700 Red blood cell-mediated enhancement of hematopoietic stem cell functions via Hes1-dependent pathway 8 samples shares hes1
- GSE249206 Piezo1 balances the osteogenic-tenogenic plasticity of periosteal progenitor cells through the YAP pathway 2 samples shares piezo1
- GSE277264 Role of Piezo1-mediated mechanotransduction in osteocyte differentiation 12 samples shares piezo1
- GSE297515 Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging 90 samples shares piezo1
- GSE297134 PIEZO1 mediates mechanical reprogramming of neutrophils for proangiogenic specialization in the lung 23 samples shares piezo1
- GSE293094 Piezo1 initiates host immune defense against pathogenic fungi through mechanosensory recognition of Candida albicans hyphae 12 samples shares piezo1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.