Piezo1 initiates host immune defense against pathogenic fungi through mechanosensory recognition of Candida albicans hyphae
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × RNA_WT_PBS vs 3 × RNA_WT_CA vs 3 × RNA_Piezo1KO_DMSO vs 3 × RNA_Piezo1KO_CAGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Piezo1 senses hyphae and initiates host defense against pathogenic fungiCell reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE293094_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1242795 and SRA study SRP573725. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8876047 RNA_WT_PBS_rep1 RNA_WT_PBS
- GSM8876048 RNA_WT_PBS_rep2 RNA_WT_PBS
- GSM8876049 RNA_WT_PBS_rep3 RNA_WT_PBS
- GSM8876050 RNA_WT_CA_rep1 RNA_WT_CA
- GSM8876051 RNA_WT_CA_rep2 RNA_WT_CA
- GSM8876052 RNA_WT_CA_rep3 RNA_WT_CA
- GSM8876053 RNA_Piezo1KO_DMSO_rep1 RNA_Piezo1KO_DMSO
- GSM8876054 RNA_Piezo1KO_DMSO_rep2 RNA_Piezo1KO_DMSO
- GSM8876055 RNA_Piezo1KO_DMSO_rep3 RNA_Piezo1KO_DMSO
- GSM8876056 RNA_Piezo1KO_CA_rep1 RNA_Piezo1KO_CA
- GSM8876057 RNA_Piezo1KO_CA_rep2 RNA_Piezo1KO_CA
- GSM8876058 RNA_Piezo1KO_CA_rep3 RNA_Piezo1KO_CA
- GSE279850 Piezo1 initiates host immune defense against pathogenic fungi through mechanosensory recognition of Candida albicans hyphae 12 samples shares piezo1, mechanosensory, recognition, pathogenic, initiates, albicans, defense, against
- GSE279743 Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 high-pathogenicity avian influenza virus with reduced adverse reactions (using whole lymph node) 9 samples shares pathogenic, against
- GSE297515 Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging 90 samples shares piezo1
- GSE297134 PIEZO1 mediates mechanical reprogramming of neutrophils for proangiogenic specialization in the lung 23 samples shares piezo1
- GSE276391 The pivotal role of the Hes1–Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosis 20 samples shares piezo1
- GSE298695 Mechanosensing by endothelial Piezo1 promotes liver regeneration after partial hepatectomy via ATF2-ID1-Wnt2 pathway 16 samples shares piezo1
- GSE283887 Piezo1 promotes the progression of necrotizing enterocolitis via activating Ca2(+)/CaMKII-dependent pathway 12 samples shares piezo1
- GSE277264 Role of Piezo1-mediated mechanotransduction in osteocyte differentiation 12 samples shares piezo1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.