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KMT2D is essential for cerebellar granule cell differentiation

GSE281630 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/11/14 Platform GPL34290
Summary
The cerebellum contains 62%‒73% of the total number of neurons in the mouse brain. Granule cells (GCs) constitute the vast majority of cerebellar neurons. Single cell RNA-seq analyses showed that Atoh1-Cre-mediated knockout (KO) of the Kmt2d gene encoding the lysine methyltransferase KMT2D (MLL4 and a COMPASS-like enzyme) in the cerebellar GC lineage in mice inhibited cerebellar GC differentiation and downregulated neuron differentiation expression programs. In addition, Kmt2d KO inhibited the transition of GC progenitors to GCs while having a cell-non-autonomous impact on other cerebellar cells.
Published in
KMT2D temporally activates neuronal transcriptional factor genes to mediate cerebellar granule cell differentiation
Dhar SS, Ko KP, Jang J et al. · Science advances 2025 · PMID 41004595 · doi:10.1126/sciadv.adu7174
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Also filed as BioProject PRJNA1184848 and SRA study SRP544678. Searching any of these in the dataset finder brings you back here.

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