Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × Pnoc_LepR_KO_Input vs 4 × Pnoc_LepR_KO_Pulldown vs 4 × Pnoc_LepR_WT_Input vs 4 × Pnoc_LepR_WT_PulldownGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasisCell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292416_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1238345 and SRA study SRP571670. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8858611 Pnoc_LepR_KO_Input_5 Pnoc_LepR_KO_Input
- GSM8858612 Pnoc_LepR_KO_Input_6 Pnoc_LepR_KO_Input
- GSM8858613 Pnoc_LepR_KO_Input_7 Pnoc_LepR_KO_Input
- GSM8858614 Pnoc_LepR_KO_Input_8 Pnoc_LepR_KO_Input
- GSM8858615 Pnoc_LepR_KO_Pulldown_5 Pnoc_LepR_KO_Pulldown
- GSM8858616 Pnoc_LepR_KO_Pulldown_6 Pnoc_LepR_KO_Pulldown
- GSM8858617 Pnoc_LepR_KO_Pulldown_7 Pnoc_LepR_KO_Pulldown
- GSM8858618 Pnoc_LepR_KO_Pulldown_8 Pnoc_LepR_KO_Pulldown
- GSM8858619 Pnoc_LepR_WT_Input_1 Pnoc_LepR_WT_Input
- GSM8858620 Pnoc_LepR_WT_Input_2 Pnoc_LepR_WT_Input
- GSM8858621 Pnoc_LepR_WT_Input_3 Pnoc_LepR_WT_Input
- GSM8858622 Pnoc_LepR_WT_Input_4 Pnoc_LepR_WT_Input
- GSM8858623 Pnoc_LepR_WT_Pulldown_1 Pnoc_LepR_WT_Pulldown
- GSM8858624 Pnoc_LepR_WT_Pulldown_2 Pnoc_LepR_WT_Pulldown
- GSM8858625 Pnoc_LepR_WT_Pulldown_3 Pnoc_LepR_WT_Pulldown
- GSM8858626 Pnoc_LepR_WT_Pulldown_4 Pnoc_LepR_WT_Pulldown
- GSE334205 Sympathetic Neurons Restrain Pancreatic Cancer Lung Metastatic seeding through NPY-NPY1R Signaling [scRNA-seq] 16 samples shares npy, neurons
- GSE262033 m6A methyltransferase Mettl3 is essential for neuronal homeostasis and sleep via modulating Npy in mice 12 samples shares npy, homeostasis
- GSE334016 Sympathetic Neurons Restrain Pancreatic Cancer Lung Metastatic seeding through NPY-NPY1R Signaling [barcode] 11 samples shares npy, neurons
- GSE292387 Medial preoptic PNOC neurons constrain brown adipose tissue thermogenesis and energy expenditure 10 samples shares pnoc, neurons
- GSE306829 Medial preoptic PNOC neurons constrain brown adipose tissue thermogenesis and energy expenditure 6 samples shares pnoc, neurons
- GSE310235 Canopy1/Cnpy1 is required for proper V2R processing and transport; its functional loss impairs basal/V2R vomeronasal sensory neurons function and circuit organization. 1 samples shares npy, neurons
- GSE291295 Single-Cell Resolution of Individual Variation in Hypothalamic Neurons Allows Targeted Manipulation Affecting Social Motivation 36 samples shares hypothalamic, neurons
- GSE275887 Investigating the potential molecular mechanisms of mogroside V on glucose homeostasis by transcriptome profiling of adult mouse hypothalamic cells 24 samples shares hypothalamic, homeostasis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.