H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (ChIP-seq)
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 24 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbationsMolecular cell · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296977_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1262309 and SRA study SRP585102. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8981003 mWT1A_input
- GSM8981004 mWT2A_input
- GSM8981005 mSCADD1A_input
- GSM8981006 mSCADD2A_input
- GSM8981007 mWT1A_H3K9ac
- GSM8981008 mWT2A_H3K9ac
- GSM8981009 mSCADD1A_H3K9ac
- GSM8981010 mSCADD2A_H3K9ac
- GSM8981011 mWT1A_H4K16ac
- GSM8981012 mWT2A_H4K16ac
- GSM8981013 mSCADD1A_H4K16ac
- GSM8981014 mSCADD2A_H4K16ac
- GSM8981015 mWT1A_H4K16bu
- GSM8981016 mWT2A_H4K16bu
- GSM8981017 mSCADD1A_H4K16bu
- GSM8981018 mSCADD2A_H4K16bu
- GSM8981019 mWT1B_H4K16pr
- GSM8981020 mWT2B_H4K16pr
- GSM8981021 mSCADD1B_H4K16pr
- GSM8981022 mSCADD2B_H4K16pr
- GSM8981023 mWT1B_input
- GSM8981024 mWT2B_input
- GSM8981025 mSCADD1B_input
- GSM8981026 mSCADD2B_input
- GSE296976 H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (ATAC-seq) 8 samples shares h4k16, dehydrogenase, short-chain, acylations, deficiency, fine-tune, acyl-coa
- GSE296978 H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (RNA-seq) 6 samples shares h4k16, dehydrogenase, short-chain, acylations, deficiency, fine-tune, acyl-coa
- GSE275933 H4K16 acylations fine-tune transcriptional response during metabolic perturbations (ChIP-seq) 46 samples shares h4k16, acylations, fine-tune, chip-seq
- GSE275932 H4K16 acylations fine-tune transcriptional response during metabolic perturbations (ATAC-seq) 4 samples shares h4k16, acylations, fine-tune
- GSE275934 H4K16 acylations fine-tune transcriptional response during metabolic perturbations (RNA-seq) 4 samples shares h4k16, acylations, fine-tune
- GSE309626 Acute Arrhythmias in a Long-chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHADD) Mouse Model 12 samples shares dehydrogenase, deficiency, acyl-coa
- GSE282759 Raising NAD+ Level Stimulates Short-Chain Dehydrogenase/Reductase Proteins to Alleviate Heart Failure Independent of Mitochondrial Protein Deacetylation 16 samples shares dehydrogenase, short-chain
- GSE317551 Aldehyde dehydrogenase 2 deficiency exacerbates alcohol-associated liver fibrosis 15 samples shares dehydrogenase, deficiency
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.