GEO series
H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (ChIP-seq)
GSE296977
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
24 samples
2026/01/13
GPL21103
Summary
We investigated the combined effects of H4K16 acylations in vivo using a mouse model of short-chain acyl-CoA dehydrogenase deficiency (SCADD), which causes metabolic challenges and systemic shifts in acyl-CoA ratios. Our findings indicate that H4K16 acylations modulate transcriptional responses in a concerted manner, providing insights into an adaptive chromatin regulation in response to metabolic stress.
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Paper (PMID 41421336) ↗
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