Single-Cell RNA-Seq Study Showing the Effect of Healthy and Cencer Cells on HSCs
Single-cell RNA-seq · human · 16 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 4 × Gene expression of CD34 BM cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well vs 4 × ADT expression of CD34 BM cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well vs 4 × Gene expression of CD34 PB cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well vs 4 × ADT expression of CD34 PB cells samples treated by cancers and primary tissue exosomes and one untreated sample, WellGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Enhanced hematopoietic stem cell self-renewal and engraftment through human lung exosomal communicationMolecular therapy : the journal of the American Society of Gene Therapy · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE305700_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1307482 and SRA study SRP609849. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9181932 Gene expression of CD34 BM cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well1 Gene expression of CD34…
- GSM9181933 Gene expression of CD34 BM cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well2 Gene expression of CD34…
- GSM9181934 Gene expression of CD34 BM cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well3 Gene expression of CD34…
- GSM9181935 Gene expression of CD34 BM cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well4 Gene expression of CD34…
- GSM9181936 ADT expression of CD34 BM cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well1 ADT expression of CD34 …
- GSM9181937 ADT expression of CD34 BM cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well2 ADT expression of CD34 …
- GSM9181938 ADT expression of CD34 BM cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well3 ADT expression of CD34 …
- GSM9181939 ADT expression of CD34 BM cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well4 ADT expression of CD34 …
- GSM9181940 Gene expression of CD34 PB cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well1 Gene expression of CD34…
- GSM9181941 Gene expression of CD34 PB cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well2 Gene expression of CD34…
- GSM9181942 Gene expression of CD34 PB cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well3 Gene expression of CD34…
- GSM9181943 Gene expression of CD34 PB cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well4 Gene expression of CD34…
- GSM9181944 ADT expression of CD34 PB cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well1 ADT expression of CD34 …
- GSM9181945 ADT expression of CD34 PB cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well2 ADT expression of CD34 …
- GSM9181946 ADT expression of CD34 PB cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well3 ADT expression of CD34 …
- GSM9181947 ADT expression of CD34 PB cells samples treated by cancers and primary tissue exosomes and one untreated sample, Well4 ADT expression of CD34 …
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- GSE278688 Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [scRNA-Seq] 29 samples shares single-cell, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.