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Sulforaphane alleviates hepatocyte pyroptosis via activating Nrf2-HO-1 signaling during septic acute liver injury

GSE305948 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/12/03 Platform GPL24247
Summary
Acute liver injury (ALI) caused by sepsis is a fatal disease with a high mortality rate and poor prognosis. Sulforaphane (SFN) is a natural isothiocyanate that has robust antioxidant and anti-inflammatory properties. The aim of this study was to identify the pharmacological effects and therapeutic mechanisms of SFN in lipopolysaccharide (LPS)-induced ALI.
Published in
Sulforaphane alleviates hepatocyte pyroptosis via activating Nrf2-HO-1 signaling during septic acute liver injury
Xie S, Liu M, Chen L et al. · Frontiers in pharmacology 2025 · PMID 41181585 · doi:10.3389/fphar.2025.1690067
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Also filed as BioProject PRJNA1308495 and SRA study SRP610129. Searching any of these in the dataset finder brings you back here.

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