GEO series
Effects of norepinephrine(NE) and dexamethasone(DEX) exposure on signaling pathways in immortalized primary human trabecular meshwork cells.
GSE336386
Homo sapiens
Expression profiling by high throughput sequencing
9 samples
2026/06/30
GPL28038
Summary
Aqueous humor drainage through the trabecular meshwork is regulated in part by hormonal cues, including norepinephrine (NE) and dexamethasone (DEX), and its circadian variation is thought to reflect rhythmic changes in these signals. However, the transcriptional programs and molecular pathways through which NE and DEX influence human trabecular meshwork cells remain incompletely defined. In this study, we performed RNA-seq analysis of immortalized human primary trabecular meshwork cells (abm; T0371) exposed to NE or DEX for 6 hours, with vehicle-treated cells as controls, to identify stimulus-responsive genes and pathways associated with trabecular meshwork function and aqueous humor outflow.
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