Ablation of Hepatic CPT1a Lowers Plasma Cholesterol Levels.
RNA-seq (gene expression) · mouse · 23 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 23 samples: 6 × B100-LKO Male vs 6 × B100-Control Female vs 6 × B100-LKO Female vs 5 × B100-Control MaleGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers ApoB-Containing Lipoproteins in MiceArteriosclerosis, thrombosis, and vascular biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277404_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1162113 and SRA study SRP533253. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 23 samples.
How we read this: 4 replicated groups read from 23 sample titles; they account for 23 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8521723 B100-Control Male-1 B100-Control Male
- GSM8521724 B100-Control Male-2 B100-Control Male
- GSM8521725 B100-Control Male-3 B100-Control Male
- GSM8521726 B100-Control Male-4 B100-Control Male
- GSM8521727 B100-Control Male-6 B100-Control Male
- GSM8521728 B100-LKO Male-1 B100-LKO Male
- GSM8521729 B100-LKO Male-2 B100-LKO Male
- GSM8521730 B100-LKO Male-3 B100-LKO Male
- GSM8521731 B100-LKO Male-4 B100-LKO Male
- GSM8521732 B100-LKO Male-5 B100-LKO Male
- GSM8521733 B100-LKO Male-6 B100-LKO Male
- GSM8521734 B100-Control Female-1 B100-Control Female
- GSM8521735 B100-Control Female-2 B100-Control Female
- GSM8521736 B100-Control Female-3 B100-Control Female
- GSM8521737 B100-Control Female-4 B100-Control Female
- GSM8521738 B100-Control Female-5 B100-Control Female
- GSM8521739 B100-Control Female-6 B100-Control Female
- GSM8521740 B100-LKO Female-1 B100-LKO Female
- GSM8521741 B100-LKO Female-2 B100-LKO Female
- GSM8521742 B100-LKO Female-3 B100-LKO Female
- GSM8521743 B100-LKO Female-4 B100-LKO Female
- GSM8521744 B100-LKO Female-5 B100-LKO Female
- GSM8521745 B100-LKO Female-6 B100-LKO Female
- GSE315007 Sex- and hepatocyte Pparg-dependent hepatic effects of a high fat diet containing 60% kcal from fat and 2% cholesterol, which was supplemented with 10% fructose in the drinking water (HFC+Fr) to induce diet-induced obesity in male and female mice. 30 samples shares cholesterol, hepatic
- GSE252224 Cpt1a drives lipid remodeling in primed-to-naïve pluripotency transition [RNA-Seq 1] 18 samples shares cpt1a
- GSE255949 Gene expression of alveolar macrophage in mice with AT2 cell-specific Cpt1a deletion 11 samples shares cpt1a
- GSE253147 Cpt1a drives lipid remodeling in primed-to-naïve pluripotency transition 33 samples shares cpt1a
- GSE294630 CDA HFD mice analysed for hepatic gene expression after treatment with semaglutide 97 samples shares hepatic
- GSE276155 RBBP5 is an epigenetic regulator of mammalian hepatic 12h oscillator [RNA-seq] 96 samples shares hepatic
- GSE248864 Hepatic Glucocorticoid Receptor (GR) drives the diurnal adaptation to Caloric Restriction 90 samples shares hepatic
- GSE268864 Hepatic PKA Mediates the Liver and Pancreatic Alpha-Cell Crosstalk 90 samples shares hepatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.