Drug, across the briefings
Pembrolizumab across 24 cancers
Pembrolizumab appears in 24 of the briefings; its FDA label names 20 of those diseases.
| Disease | FDA label | Open Targets stage, on which gene | Trials | Active |
|---|---|---|---|---|
| Bladder cancer | label names disease | — | — | |
| Breast cancer | label names disease | — | — | |
| Cervical cancer | label names disease | phase 4 on PDCD1 | 48 | 21 |
| Cholangiocarcinoma | label names disease | — | — | |
| Colorectal cancer | label names disease | — | — | |
| Cutaneous squamous cell carcinoma | label names disease | phase 4 on PDCD1 | 33 | 18 |
| Diffuse large B-cell lymphoma | label names disease | — | — | |
| Endometrial cancer | label names disease | — | — | |
| Esophageal cancer | label names disease | phase 4 on PDCD1 | 105 | 50 |
| Gallbladder cancer | label names disease | — | — | |
| Gastric cancer | label names disease | — | — | |
| Head and neck cancer | label names disease | phase 4 on PDCD1 | 148 | 63 |
| Hepatocellular carcinoma | label names disease | — | — | |
| Hodgkin lymphoma | label names disease | phase 4 on PDCD1 | 61 | 26 |
| Kidney cancer | label names disease | — | — | |
| Lung cancer | label names disease | — | — | |
| Melanoma | label names disease | phase 4 on PDCD1 | 183 | 70 |
| Merkel cell carcinoma | label names disease | phase 4 on PDCD1 | 35 | 15 |
| Mesothelioma | label names disease | phase 4 on PDCD1 | 45 | 17 |
| Ovarian cancer | label names disease | — | — | |
| Anal cancer | phase 4 on PDCD1 | 16 | 9 | |
| Basal cell carcinoma | phase 4 on PDCD1 | 5 | 3 | |
| Nasopharyngeal carcinoma | phase 4 on PDCD1 | 23 | 11 | |
| Vulvar cancer | phase 4 on PDCD1 | 8 | 4 |
The label column is the briefing's openFDA stage: a label whose Indications and Usage names the disease. The Open Targets column is the furthest clinical stage recorded for the drug against any gene on that briefing's target list, in any indication. Trials are ClinicalTrials.gov interventional studies naming the drug and the disease, from the briefing's trials stage; a dash means the briefing did not search this drug in that disease (it searches the drugs Open Targets lists against its own genes), which is not the same as none. Salt forms, biosimilar suffixes and formulation words are merged by the same rule the briefings use.