Disease landscape briefings

One compiled landscape per disease: what can be aimed at each recurrently implicated gene, which trials are running in the disease itself, which public datasets are worth reusing, and where the funding goes. Every figure carries the API it came from and the date it was retrieved.

Across them: disease burden and research capital — cases, deaths, survival, years of life lost and NIH dollars per life-year, 53 cancers on one table — and one page per gene or drug that appears in two or more briefings: targets across the briefings and drugs across the briefings. Where a disease has sequenced cohorts on cBioPortal, its tile says "mutations" and the briefing links a mutation landscape.

Blood and lymph

14 diseases, by US cases a year · 14 with a drug labelled for the disease itself

Digestive

10 diseases, by US cases a year · 10 with a drug labelled for the disease itself

Thoracic

3 diseases, by US cases a year · 3 with a drug labelled for the disease itself

Lung cancer 229,410 cases · 47 labelled drugs · 1253 trials · mutations Small cell lung cancer 29,823 cases (est.) · 4 labelled drugs · 577 trials · mutations Mesothelioma 3,000 cases · 4 labelled drugs · 234 trials · mutations

Breast and gynaecological

5 diseases, by US cases a year · 5 with a drug labelled for the disease itself

Breast cancer 321,910 cases · 38 labelled drugs · 1135 trials · mutations Endometrial cancer 68,270 cases · 6 labelled drugs · 249 trials · mutations Ovarian cancer 21,010 cases · 9 labelled drugs · 409 trials · mutations Cervical cancer 13,490 cases · 3 labelled drugs · 328 trials · mutations Vulvar cancer 7,130 cases · 1 labelled drug · 44 trials · mutations

Genitourinary

5 diseases, by US cases a year · 5 with a drug labelled for the disease itself

Prostate cancer 333,830 cases · 25 labelled drugs · 775 trials · mutations Bladder cancer 84,530 cases · 10 labelled drugs · 548 trials · mutations Kidney cancer 80,450 cases · 16 labelled drugs · 929 trials · mutations Testicular cancer 9,810 cases · 1 labelled drug · 24 trials · mutations Wilms tumour 600 cases · 1 labelled drug · 101 trials · mutations

Brain and nervous system

4 diseases, by US cases a year · 4 with a drug labelled for the disease itself

Glioblastoma 13,073 cases · 3 labelled drugs · 91 trials · mutations Lower-grade glioma 3,778 cases (est.) · 2 labelled drugs · 5 trials · mutations Neuroblastoma 650 cases · 3 labelled drugs · 134 trials Medulloblastoma 431 cases · 1 labelled drug · 26 trials · mutations

Bone and soft tissue

4 diseases, by US cases a year · 3 with a drug labelled for the disease itself

Soft tissue sarcoma 13,910 cases · 7 labelled drugs · 209 trials · mutations Osteosarcoma 1,000 cases · 0 labelled drugs · 109 trials · mutations Ewing sarcoma count not published · 1 labelled drug · 36 trials · mutations Rhabdomyosarcoma count not published · 1 labelled drug · 57 trials · mutations

Skin, head and neck, endocrine

8 diseases, by US cases a year · 8 with a drug labelled for the disease itself

Basal cell carcinoma 4,320,000 cases (est.) · 4 labelled drugs · 161 trials · mutations Cutaneous squamous cell carcinoma 1,080,000 cases (est.) · 3 labelled drugs · 166 trials · mutations Melanoma 112,000 cases · 16 labelled drugs · 1087 trials · mutations Head and neck cancer 60,480 cases (est.) · 3 labelled drugs · 924 trials · mutations Thyroid cancer 45,240 cases · 13 labelled drugs · 184 trials · mutations Merkel cell carcinoma 3,000 cases · 3 labelled drugs · 146 trials · mutations Nasopharyngeal carcinoma count not published · 2 labelled drugs · 457 trials · mutations Uveal melanoma count not published · 1 labelled drug · 159 trials · mutations

Cases are the source's US annual estimate; "(est.)" marks a figure derived from a broader category and a published share. Machine-readable: /disease/api.json.

A briefing is an overview. To work from a target list, use the Neuroblastoma Surface Targets atlas; to find datasets for a question of your own, use the GEO Dataset Finder. Method and sources: how these are built.